Neuner1 animal documentation

Motor function, spatial learning and memory function, anxiety-related behaviors, and beta-amyloid levels in Alzheimer’s Disease mouse models (AD-BXD)   (2019)

Neuner SM, Kaczorowski CC
With: Heuer SE, Huentelman MJ, O’Connell KMS, Zhang JG, Philip VM

Animal documentation

Source Female C57BL/6J mice hemizygous for the 5XFAD transgene (B6.Cg-Tg(APPSweFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax, Stock No. #34848-JAX) were mated to males from the BXD genetic reference panel (from University of Tennessee Health Science Center). As female B6.5XFAD mice are hemizygous, transgenic (ADtg) and non-transgenic (Ntg) F1 mice are generated.
Mice tested at 8-65 wks of age

Not specified, provided ad libitum

Provided ad libitum
Not specified
Not specified

Mice were group housed at the University of Tennessee Health Science Center

Photoperiod 12:12h
Care and Use
Experiments were carried out in accordance with the standards of the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC), as well as the recommendations of the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The protocol was approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Tennessee Health Science Center.