HMDPpheno11 animal documentation

Diet effects on aortic lesion size in 103 Hybrid Mouse Diversity Panel strains that are transgenic for human APOE*3Leiden and human CETP (F1 hybrids)   (2015)

Bennett BJ, Lusis AJ
With: Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS

Animal Documentation

Source of Mice: Mice carrying the human transgene for cholesterol ester transfer protein (CETP) were obtained from The Jackson Laboratory (Stock number 003904); mice carrying the human ApoE*3 Leiden variant were provided by Dr L. Havekes at Leiden University Medical Center, Leiden, The Netherlands. Common inbred and recombinant inbred of the Hybrid Mouse Diversity Panel were obtained from The Jackson Laboratory.

Age (wks): 23-25wks

Breeding: Transgenic animals were bred to produce a C57BL/6J strain carrying both human APOE*3Leiden and human transgenes. Males transgenic for both transgenes were bred to females of common inbred and recombinant inbred strains of the Hybrid Mouse Diversity Panel.

Feed: Chow or experimental diet

Water: Water ad libitum

Temperature (°C): Not specified

Humidity (%): Not specified

Light / Dark Cycle: 12:12h (lights on 0600h)

Care and Use Statement: All experiments were conducted according to relevant national and international guidelines and was approved by the UCLA Animal Research Committee, the UCLA IACUC.