Feng1: Genetic analysis of blood pressure in 8 mouse intercross populations (2009)

Feng M, Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, Churchill GA, DiPetrillo K. Genetic analysis of blood pressure in 8 mouse intercross populations. Hypertension. 2009 Oct;54(4):802-9. Epub 2009 Aug 3.   PubMed 19652078  


       
Feng1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Investigators M Feng
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, DiPetrillo K
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsGrants: This work was supported by the Novartis Institutes for BioMedical Research.
Project type QTL Archive data set
MPD identifiersFeng1     MPD:216
Data changelog No updates/corrections.       Initial release date: 08/2010.
To study the genetic basis of hypertension (high blood pressure) and identify the genes that cause common forms of hypertension, eight F2 intercross with 2,577 male mice was generated to perform QTL analyses of blood pressure. The F2 population was produced from 14 inbred strains (129, A, D2, AKR, NZW, BTBR, SWR, C3H, KK, FVB, RIII, SJL, PL and CBA) and tail-cuff blood pressure was measured when mice were 8 weeks old. For detailed protocols see Feng et al 2009.


QTL data set parameters:
Cross 1: 129S1/SvImJ x A/J       Feng1
Progenitor strains 129S1/SvImJ     A/J    
Cross direction notation(129xA) F1 x (129xA) F1
Cross typeF2 intercross
Population size 0 ♀     336 ♂
Age8wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Bpq14   Bpq15   Bpq16   Bpq17   Bpq18   Bpq19   Bpq20   Bpq24   Bpq25   Bpq26   Bpq27   Bpq28   Bpq29   Bpq30  


Cross 1: 129S1/SvImJ x A/J     Feng1     a.k.a. Feng_2009a
Excel file:   Data_Description_129xAJ_Feng2009.xlsx
CSV file:   Feng2009_129xAJ_B37_Data.csv
Readme / text file:   readme_Feng2009a.txt
QC plots, figures, etc.:   QCReport_Feng2009a.pdf